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KMID : 0614620080520040247
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Korean Journal of Gastroenterology
2008 Volume.52 No. 4 p.247 ~ p.250
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A Case of Familial Crohn’s Disease Observed in a Parent and His Offspring
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Cho Hyun-Seok
Byun Tae-Jun
Ahn Sang-Bong
Kim Tae-Yeob
Eun Chang-Soo
Jeon Yong-Cheol
Kim Yong-Seok
Han Dong-Soo
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Abstract
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Crohn’s disease (CD), one of the major forms of idiopathic inflammatory bowel disease (IBD), is thought to be related to genetic susceptibility coupled with environmental factors. A positive family history is the strongest risk factor for the development of CD. The 10-fold increase in the familial risk of CD strongly suggests that these disorders have a genetic background. The prevalence of IBD in Asian populations is lower than in Western populations, which may be due to genetic influences, environmental factors, or a combination of both. In a Korean study, only 0.25% of parents had IBD in CD probands and all of them had ulcerative colitis. The term of familial CD was used only for those with one or more first-degree relatives with confirmed CD. There are few case reports about familial Crohn’s disease in Korea. We report a case of familial CD that the father, the first degree relative was diagnosed as small bowel CD after confirming his son as having CD.
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KEYWORD
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Familial, Crohn’s disease
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